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KMID : 1036020210100030322
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지질.동맥경화학회지
2021 Volume.10 No. 3 p.322 ~ p.333
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Statin Therapy and the Risk of Osteoporotic Fractures in Patients with Metabolic Syndrome: a Nested Case-Control Study
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Kim Kyoung-Jin
Choi Ji-Mi
Kim Ji-Yoon
Bae Jae-Hyun
Kim Kyeong-Jin
Kim Hee-Young
Yoo Hye-Jin
Seo Ji-A
Kim Nan-Hee
Choi Kyung-Mook
Baik Sei-Hyun
Kim Sin-Gon
Kim Nam-Hoon
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Abstract
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Objective: We aimed to investigate the association between statin use and the risk of major osteoporotic fractures in patients with metabolic syndrome (MetS).
Methods: A nested case-control study was performed in patients with MetS (≥50 years) who had no history of osteoporotic fracture using the Korean National Health Insurance Service-Health Screening Cohort. This study included 17,041 patients diagnosed with new-onset osteoporotic fractures and controls matched in a 1:1 ratio by age, sex, body mass index, cohort entry date, and follow-up duration. Conditional logistic regression analysis was used to evaluate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs).
Results: During a 4-year follow-up period, the risk of major osteoporotic fractures was significantly reduced by 9% (OR, 0.91; 95% CI, 0.85?0.97) in statin users compared with that in non-users. Among subtypes of major osteoporotic fracture, a risk reduction with statin therapy was significant for vertebral fracture (OR, 0.86; 95% CI, 0.79?0.94) but not for non-vertebral fracture (OR, 0.97; 95% CI, 0.88?1.06). Longer duration (OR, 0.97; 95% CI, 0.96?0.99, per 1-year increase) and higher cumulative dose (OR, 0.97; 95% CI, 0.95?0.99, per 365 defined daily doses) of statins were negatively associated with the risk of major osteoporotic fracture.
Conclusion: This study supports the hypothesis that statin therapy has a beneficial effect on major osteoporotic fractures, especially vertebral fractures, in patients with MetS.
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KEYWORD
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HMG-CoA reductase inhibitor, Statin, Osteoporotic fractures, Metabolic syndrome, Case-control studies
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